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Index >> Protein Synthesis >> Nomenclature of Prokaryotic and Eukaryotic Initiation Factors

Nomenclature of Prokaryotic and Eukaryotic Initiation Factors

Nomenclature of Prokaryotic and Eukaryotic Initiation Factors

Prokaryotes Eukaryotes Molecular Weight (form rabbit reticulocytes)
  Anderson (1975) nomenclature(1) Ochoa (1976) nomemclature (2)
IF-1* IF-MP eIF-2** 90,000
IF-2** IF-MI eIF-2'** 65,000
  IF-M2A eIF-2a1*** 125,000
  IF-M2Bα eIF-2a2*** 16,000
  IF-M2Bß eIF-2a3*** 19,500
IF-3*** IF-M3 eIF-3**** 400,000

(1) Adams, S. L., Safer, B. Anderson, W. F. (1975). J. Biol. Chem. (2) Weissbach, H. and Ochoa, S. (1976). Ann. Rev. Biochem. 45: 191"216.
* There is no eukaryotic equivalent of IF-I.
** IF-2 is functionally equivalent to eIF-2 and eIF-2'.
*** There is no prokaryotic equivalent of the accessory factors eIF-2a, elF-2a and elF-2a of eukaryotes.
**** IF-3 is equivalent to eukaryotic eIF-3.

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