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Index >> Regulation of Protein Synthesis - Operon >> Frenster's Model of Gene Regulation

Frenster's Model of Gene Regulation

Frenster's Model of Gene Regulation

- Histones stabilize the DNA double helix by interacting with the negative phosphate groups of DNA.

This prevents the separation of strands, and consequently transcription.

The histones thus act as general repressors of protein synthesis.

Histones are displaced from DNA by nuclear polyions which form complexes with histones.

This permits separation of the DNA strands in a random manner.

Gene specific derepressor RNA hybridizes with the non transcribing DNA strand at a particular locus and stabilizes the loop in the open position.

This frees the other DNA strand and permits it to transcribe messenger RNA.

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