Index >> Replication of DNA >> E.Coli DNA Synthesis Genes

E.Coli DNA Synthesis Genes - The overall process of replication requires the products of genes dnaA, dnaB, dnaC-D, dnaE, and dnaG. The products of genes dnaA and dnaC-D are required for initiating new rounds of replication and the products of dnaE and dnaG for replication fork movement. The dnaG protein appears to be necessary for initiation of synthesis of DNA fragments.

The locus for the origin of replication is at 74 minutes, and that for terminatiosn of replication at 25 minutes. The structural genes for the three DNA polymerases are polA (for polymerase I), polB (for polymerase II) and dnaE (for polymerase III and polymerase III*).