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Main Index >> Replication of DNA

* Replication of DNA
* Outline of Replication
* Replication During Interphase
* Semi Conservative Replication Process
* Mechanism of Replication
* E.Coli DNA Synthesis Genes
* Genes Involve in Replication in E.Coli
* Incision
* Origin
* Role of Membranes
* Unwinding of the Strand
* Superhelix Realxing Protein - Swiveling Protein
* Template DNA
* RNA Primer
* Chain Elongation
* Replication Direction
* Replicating Forks
* Okazaki Fragments
* Polynucleotide Ligase
* DNA Polymerases
* Polymerase I - Pol I
* 5' --> 3' Polymerization
* 3' --> 5' Exonuclease Activity
* 5' --> 3' Exonuclease Activity
* Difference Between 3' --> 5' and 5' --> 3' Exonuclease Activity
 

Replication of DNA


Replication of DNA - One of the most important properties of DNA is that it can make exact copies of itself. This process is called replication, and is the very basis of life. The two strands of a DNA double helix are united by hydrogen bonds between the purine and pyrimidine base pairs. When the hydrogen bonds break the two strands separate and unwind. The nucleus contains free nucleotides which form the nucleotide pool. The nucleotides include those containing adenine, guanine, cytosine and thymine nitrogenous bases. These free nucleotides pair with the nucleotides of the two separated strands by means of hydrogen bonds.

Free adenine nucleotide pairs with the thymine nucleotide of the strand, and free guanine nucleotide with the cytosine nucleotide of the strand, etc. (A-T and G-C pairing). In this way a new strand is formed around each old strand. The result of replication is the formation of two double helices, each identical to the original double helix. DNA is found mostly in the chromosomes. When the chromosome divides into two during mitosis the two daughter chromosomes have identical DNA double helices.

Now, all the cell, in the body are ultimately derived from the zygote by repeated division. It thus follows that they all have exactly similar DNA. Replication ensures that the genes, which are segments of the DNA molecule, are present in identical sets in all cells of the body of an individual. DNA fulfils the requirement of a genetical materials the ability to replicate.

* Polymerase II - Pol II
* Polymerase III - Pol III
* Characteristics of DNA Polymerases
* Eukaryotic DNA Polymerases
* Models of Replication
* Cairns Model of Replication
* Yoshikawa Model of Replication
* Rolling Circle Model of Replication
* Replication in Duplex Rod Prokaryote Chromosome
* Replication in Eukaryote Chromosome
* Repair Replication
* Functions of DNA