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Classification
of
tRNA - A Study of different tRNAs shows that the structure of the acceptor stem, the anticodon arm and the TψC arm are constant. The differences in the tRNAs lie in the D arm and the variable arm. Based on the differences in these two variable regions, three classes of tRNA have been recognized.
Class I (D4-V4-5), with 4 base pairs in the D stem and 4-5 bases in the variable loop.
Class II (DS-V4-5), with 3 base pairs in the D stem and 4-5 bases pairs in the variable loop.
Class III (D3-VN), with 3 base pairs in the D stem and a large variable arm.
A simpler classification based only on the variable arm recognizes two types of tRNA.
Class I with 4-5 bases in the variable loop
Class II with a large variable arm of 13-21 bases.
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