Tertiary Structure of Transfer - tRNA

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Ribose Nucleic Acids Comparison Between DNA and RNA Ribosomal RNA (rRNA) Characteristics of Different Ribosome Types Types of rRNA Synthesis of rRNA Messenger RNA (mRNA) Size of mRNA Structure of mRNA Stability of mRNA Synthesis of Messenger RNA - mRNA Polyadenylation Capping in mRNA Methylation in mRNA Heterogenous Nuclear RNA (hnRNA)

Tertiary Structure of Transfer - tRNA

Tertiary Structure of Transfer - tRNA - Electron density maps have revealed that tRNA has a tertiary structure. This structure is due to hydrogen bonds

(i) between bases,

(ii) between bases and ribose phosphate backbone and

(iii) between the backbone residues. (The hydrogen bonding in the double helical stem regions of the tRNA molecular are considered to be in the secondary structure).

A description of yeast phenylalanine tRNA (tRNAphe) will illustrate the tertiary structure of tRNA. tRNAphe is a somewhat flattened L shaped molecule. 20-25A thick, with one limb being formed by the acceptor and TψC stems and the other by the D and the anticodon stems. The polynucleotide chain undergoes a sharp bend near residues 9, 10 and 11. The acceptor stem and the TψC stem are practically collinea

The D stem and the anticodon stems are, however, not in the same straight line, And their axes may deviate by as much as 25º. There are 10 base – base hydrogen bondings which maintain the bases in two stacking domains corresponding to the two limbs of the tRNA molecule. In addition there are 9 base backbone interactions which stabilize the various parts of the tRNA molecule.

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Difference Between Prokaryotes and eukaryotes mRNA Transfer RNA (tRNA) OR Soluble RNA (sRNA) Structure of Transfer RNA - tRNA Unusual Bases in tRNA Classification of tRNA Invariant and Semi invariant Nucleotides Tertiary Structure of tRNA Initiator tRNA Specificity of tRNA Biosynthesis of tRNA Comparison of Different Types of RNA

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