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Index >> Ribosomes >> Homology Between Mitoribosomes and Bacterial Ribosomes

Homology Between Mitoribosomes and Bacterial Ribosomes

Homology Between Mitoribosomes and Bacterial Ribosomes - To support the theory of the endosymbiotic origin of mitochondria several homologies between the protein synthesis systems of mitochondria and bacteria have been cited.

The diversity of mitoribosomal types is, however, so great that it is not possible to consider mitoribosomes homologous to bacterial ribosomes solely on the basis of size or S values.

A number of homologies, however, do exist between the two types of ribosomes, which are not found in cytoribosomes of higher cells.

These include:

1) Suceptibility to antibiotics like chloramphenicol, erythromycin, tylosin, venanamycin, etc.

2) Similarities in physical properties like sedimentation coefficients, molecular weights and bouyant densities.

3) Requirements of relatively high levels of Mg++ for stability.

4) Dissociation of both ribosomal types by initiating factor IF-3.

5) Involvement of fMet-tRNA in protein synthesis initiation.

6) Interchangeability of elongation factors EF-G and EF-T. The differences as well as similarities between mitoribosomes and bacterial ribosomes suggest that the different mitoribosomal types may have arisen from separate endosymbioses.

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