Lake's
Model
of
Ribosome
Structure -
In
Lake's
model
the
305
subunit
is
considered
to
be
completely
asymmetrical.
An
indentation
divides
the
subunit
into
two
unequal
parts,
referred
to
as
the
upper
one
third
(head)
and
the
lower
two
third
(body).
Extending
from
the
lower
two
third
is
a
region
called
the
platform.
There
is
a
cleft
between
the
platform
and
the
upper
one
third.
This
cleft
is
an
important
functional
region.
It
has
been
proposed
as
the
site
of
the
codon
anticodon
interaction
and
as
a
part
of
the
binding
site
for
initiation
factors
IF-I,
IF-2
and
IF-3.





