Microbiology Procedure
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Index >>Viruses and Cancer >> Oncogenic Viruses (Papovaviruses)

Oncogenic Viruses (Papovaviruses)

Oncogenic Viruses (Papovaviruses) - Of the DNA tumour viruses (parvoviruses, papovaviruses, adenoviruses herpesviruses and poxviruses, the papovaviruses have received particular attention because they are known to cause tumours in a variety of animals.
The name papovavirus is derived from the first two letters of the three prototypes: rabbit papilloma virus, polyoma virus and siman vacuolating virus 40 (SV 40).
The capsid of the papilloma polyoma group consists of 72 morphological units assembled from 420 structure units (T=7).
The surface lattice is skewed and the skewing may be right handed or left handed.

The virion consists of only DN A and protein. The capsid proteins consist of one major polypeptide, VPI, and two minor polypeptides VP2 and VP3.
The latter two polypeptides have largely identical amino acid sequences In addition to these virus specified proteins, cellular histones are associated with viral DNA
The genome of papovaviruses consists of a single, c1osed circular dsDNA molecule.
It encodes the viral proteins and also an early protein that bas an important role in the life cycle of the virus.

 

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